Postdoctoral Researcher

UHN is Canada's #1 hospital and the world's #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.

UHN's vision is to build A Healthier World and it's only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality.

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Union: Non-Union
Site: Princess Margaret Research Institution
Department: Research - Molecular and Cellular Biology
Reports to: Principal Investigator
Work Model: On-Site
Grade: VE:01
Hours: 37.5 hours per week
Salary: To commensurate with experience and consistent with UHN compensation policy
Shifts: Monday - Friday
Status: Temporary Full-time (1 year contract)
Closing Date: March 21, 2025

Position Summary
Postdoctoral positions are available in Professor Hakem's laboratory at the Princess Margaret Cancer Centre, part of the University Health Network in Toronto, Canada. Our research team is committed to exploring innovative mechanisms of cancer and identifying therapeutic vulnerabilities to develop treatments for aggressive cancers.

Professor Hakem's research program focuses on several pivotal domains: cancer genetics, DNA damage repair, genome-wide CRISPR-Cas9 screening, biochemistry, transcriptomics, epigenetics, chromatin remodeling, pharmacogenomics, and multi-omics integration. The program employs various methodologies to inform our studies, including mouse models, patient-derived xenografts, patient-derived organoids, and publicly available cancer databases, such as The Cancer Genome Atlas (TCGA). Through applying systems biology, interdisciplinary approaches, and robust collaborations with scientists, clinicians, pathologists, medicinal chemists, and computational biologists, our objective is to advance therapeutic options for patients with cancer https://orcid.org/0000-0001-5948-7931.

Our laboratory has a distinguished history of investigating cancer mechanisms and related signalling pathways. We have published our studies in prestigious peer-reviewed journals, including Nature Structural and Molecular Biology (doi:10.1038/s41594-024-01286-7), Nature Communications (doi:10.1038/ncomms12638), the Journal of Clinical Investigation (doi:10.1172/JCI140105 and doi:10.1172/JCI120401), and Nucleic Acids Research (doi.10.1093/nar/gkad172 and doi.10.1093/nar/gkad733).

Duties

• Working closely with our research team members
• Regularly updating the PI on the research progress
• Weekly data presentation at our lab meeting
• Excellent skills in writing manuscripts and fellowship application

• Expertise in cancer biology, biochemistry, or related academic disciplines is required.
• Candidates with substantial experience in DNA damage repair, transcription, and epigenetics will be prioritized.
• PhD degree in a relevant field, must be obtained within the previous 5 years.
• Candidates should exhibit high motivation and dedication to their academic pursuits.
• A robust publication record in cancer research is essential.
• Excellent written and verbal communication skills are mandatory.
• Candidates who demonstrate excellence in both independent and collaborative academic work will be prioritized.

Why join UHN?

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

• Competitive offer packages
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP https://hoopp.com/)
• Close access to Transit and UHN shuttle service
• A flexible work environment
• Opportunities for development and promotions within a large organization
• Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN's attendance management program, to be eligible for consideration.

All applications must be submitted before the posting close date.

UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.

Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.

We thank all applicants for their interest, however, only those selected for further consideration will be contacted.